Transforming growth factor beta-1 and gene polymorphisms in oriental ankylosing spondylitis
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چکیده
منابع مشابه
Transforming growth factor beta-1 and gene polymorphisms in oriental ankylosing spondylitis.
OBJECTIVES To study serum levels of transforming growth factor beta-1 (TGFbeta1) and the expression of TGFbeta1 in in vitro peripheral blood mononuclear cell (PBMC) cultures in oriental ankylosing spondylitis (AS) patients, and to determine their association with codon 10 and 25 TGFB1 gene polymorphisms. METHODS Serum levels of TGFbeta1 were measured by enzyme-linked immunosorbent assay (ELIS...
متن کاملSusceptibility to ankylosing spondylitis: no evidence for the involvement of transforming growth factor beta 1 (TGFB1) gene polymorphisms.
BACKGROUND Genetic factors are thought to be crucial in the pathogenesis of ankylosing spondylitis. Transforming growth factor beta 1 (TGF beta 1) is a multifunctional cytokine that plays a key role in inflammation. Two functional single nucleotide polymorphisms (SNPs) in the TGFB1 gene have been described: TGFB1 T869C and TGFB1 G915C. OBJECTIVE To determine whether these SNPs contribute to a...
متن کاملThe effect of transforming growth factor beta1 gene polymorphisms in ankylosing spondylitis.
OBJECTIVES To determine whether genetic polymorphisms in or near the transforming growth factor beta1 (TGFB1) locus were associated with susceptibility to or severity of ankylosing spondylitis (AS). METHODS Five intragenic single-nucleotide polymorphisms (SNP) and three microsatellite markers flanking the TGFB1 locus were genotyped. Seven hundred and sixty-two individuals from 184 multiplex f...
متن کاملTransforming Growth Factor Beta 1 869T/C and 915G/C Polymorphisms and Risk of Autism Spectrum Disorders
Background: Transforming growth factor-β1 (TGF-β1) has been found to play a crucial role in early central nervous system development. Several studies have illustrated decreased TGF-β1 levels in sera and brains of autistic children. Two point mutations in the TGF-β1 signal peptide at 869T/C and 915G/C have been reported to influence TGF-β1 expression. The aim of the pres...
متن کاملAnkylosing spondylitis, IgA, and transforming growth factors.
This hypothesis article reviews laboratory findings in seronegative arthritides with a view to discovering which cvtokines are likely to be most important in their pathogenesis. It concludes that transforming growth factors may play a significant role, and suggests that they derive from a group of T cells which have recently been rather neglected by academic immunologists. Ankylosing spondyliti...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2005
ISSN: 1460-2172
DOI: 10.1093/rheumatology/keh426